DSIP
A sleep peptide prescribed within a clinician-led sleep program that starts by finding out what is disrupting your nights.
- Explored for sleep quality and deep, slow-wave sleep
- Explored for the body's stress response
- Prescribed as part of a full sleep assessment and plan
Individual results vary. DSIP sits inside a broader sleep plan rather than standing alone, and your clinician reviews how you are sleeping at follow-up.
- Live visit with a licensed clinician
- If prescribed, medication is included in the price and delivered to your home
- Subscription, cancel anytime
Indicative price · confirmed after eligibility · prescription treatment
What DSIP is
Delta sleep-inducing peptide takes its name from delta sleep, the deep, slow-wave stage that dominates the first part of the night and that tends to decline with age.
It was isolated in Switzerland in the mid-1970s, in research where a blood fraction from rabbits in delta sleep was given to other rabbits, which then showed more delta sleep. From that blood researchers isolated a nine-amino-acid peptide and named it for the effect. A human literature followed in the late 1970s and 1980s, mostly in adults with long-standing insomnia. What the sleep evidence shows goes through it study by study.
At ACT 2, DSIP is part of a sleep program rather than a standalone product. A clinician looks at why you are sleeping badly, orders the right labs, screens for sleep apnea where your history suggests it, and builds a plan. Where DSIP fits, it is prescribed for you and dispensed by a licensed U.S. compounding pharmacy at a published monthly price.
DSIP, delta sleep-inducing peptide, is a short peptide first identified in sleep research in the 1970s and named for the deep, slow-wave stage of sleep it was studied in. It has since been explored for sleep and for the body's stress response. It is not FDA-approved; it is prepared by a licensed compounding pharmacy under an individual prescription.
How it works here
Every plan follows one path. Each step feeds the next. See the Peptide Therapy approach.
- 01
Measure
We baseline your labs, history, and goals.
- 02
Plan
A clinician decides whether this fits — and what else might serve you.
- 03
Act
If appropriate, you start with clear guidance and high-touch support.
- 04
Track
We monitor how you respond on a defined cadence.
- 05
Adjust
Protocols are refined over time. Guided care, not a kit in the mail.
Why people choose DSIP
People come to DSIP wanting better nights. Here is how the program approaches each part of that.
Most sleep problems have more than one cause, so the peptide is one part of a plan built around yours.
Better sleep starts with an assessment
Poor sleep almost always has a findable cause. Sleep-disordered breathing is the big one, badly underdiagnosed in midlife and genuinely treatable. Alcohol in the evening fragments the second half of the night. Thyroid function, iron status, perimenopausal hormone change, late caffeine, an untreated mood disorder and an overwarm bedroom all produce the symptoms that bring people to a sleep peptide.
So the program measures first: a baseline panel and, where the history points that way, a referral for a sleep study. Cognitive behavioral therapy for insomnia has a strong evidence base and may be part of your plan. Sleep that does not restore you is a good place to start.
Where DSIP fits
For people whose sleep has been properly assessed, DSIP is an option your clinician can add to the plan. It is prescribed for you individually, dispensed by a licensed U.S. compounding pharmacy, and reviewed at follow-up against the goals you set together.
If it is not the right fit, your clinician will say so and focus the plan on what is.
Prescribed, not bought online
DSIP is widely sold online labeled for research use only. That label is not a quality standard, a purity check or a medicine.
Through ACT 2, DSIP is prescribed only after a clinical assessment and prepared by a licensed U.S. compounding pharmacy, with a clinician following up on how you are sleeping.
How it works at ACT 2
A compounded preparation, dispensed by a licensed pharmacy on an individual prescription. How it is taken is set by the prescribing clinician after a review.
Who it's for
Adults over 45 whose sleep no longer restores them and who want a clinician to look at the whole picture. Screening for sleep-disordered breathing comes first, because it is common, often missed and treatable, and your plan addresses the usual drivers of poor sleep alongside any peptide. See sleep that does not restore you.
What the program includes
Every DSIP prescription at ACT 2 comes with the same clinical structure:
Clinician-led assessment and prescription. A licensed clinician reviews your history, goals and current medications, and prescribes only when it is appropriate for you.
A licensed U.S. compounding pharmacy. Your prescription is prepared individually for you by a licensed U.S. compounding pharmacy.
Baseline labs and monitoring. A Comprehensive Lab Panel before you start, and the relevant markers rechecked as you go.
A published monthly price. What you pay is on the pricing page before you book, with no hidden consult charge.
Follow-up and adjustment. Your clinician reviews progress against the goals you agreed at the start and adjusts the plan, including when to pause or stop.
No membership fee. There is no fee to be assessed, and you pay for treatment only if it is prescribed and you choose to go ahead.
For the wider context, peptide therapy explains how this category is handled here. How it works covers the process and states we serve lists where we are licensed.
Clinicians who focus on longevity
Your visit is with a licensed clinician in your state. These are the members of the medical team whose practice centers on longevity; who you see depends on your state and availability.
Medical services are provided by licensed clinicians practicing through an independent professional entity.
Often considered alongside
Sermorelin ODT
CompoundedThe needle-free route to sermorelin — offered honestly, including what we can't tell you about it.
View treatmentComprehensive Lab Panel
A comprehensive blood panel establishing your baseline across key health markers.
View treatmentProducts marked Compounded are prepared by a licensed compounding pharmacy under a prescription written for you. Compounded medications are not FDA-approved and are not equivalent to or interchangeable with any branded product.
DSIP, question by question
The specific questions people bring to this treatment, each answered on its own page and reviewed the same way this one is.
DSIP and Sleep: What the Evidence Shows
Delta sleep-inducing peptide was named for an effect in rabbits in the 1970s. What the small human sleep studies tried, and what they did not settle.
ReadDSIP Regulatory Status: The 2026 FDA Vote
In July 2026 an FDA advisory committee recommended six peptides for the 503A list and declined to recommend DSIP. What that vote was, and what it was not.
Read
What the research shows
DSIP was named for an effect seen in rabbits in the 1970s. The human sleep studies that followed are small and older, with mixed results, and long-term safety in people has not been studied. It is not FDA-approved; it is prepared by a licensed compounding pharmacy under an individual prescription. On regulation: in April 2026 the FDA removed twelve peptide substances, DSIP among them, from Category 2 of its interim 503A bulk substances list after the nominations were withdrawn. That was not a safety finding, and it did not by itself authorize compounding. In July 2026 the FDA's Pharmacy Compounding Advisory Committee reviewed seven of these peptides and voted to recommend six for the 503A Bulks List; DSIP, listed as emideltide, was the one it did not recommend. Committee votes are advisory: formal addition to the list requires notice-and-comment rulemaking, which had not completed as of September 2026. The regulatory position has the detail.
References
Government and professional-society sources consulted for this page.
- FDA Briefing Document for Emideltide-Related Bulk Drug Substances, Pharmacy Compounding Advisory Committee, July 23-24, 2026 — U.S. Food and Drug Administration (2026)
- FDA advisory committee nominates six peptides for pharmacies to compound — National Community Pharmacists Association (2026)
- Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks — U.S. Food and Drug Administration
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C Act — U.S. Food and Drug Administration
Frequently asked questions
It is named for an effect seen in early animal research, and the human studies since have been small, with mixed results, so we do not promise a sleep effect. It is prescribed as one part of a broader sleep plan. See what the sleep evidence shows.
In July 2026 it voted not to recommend DSIP, listed as emideltide, for the 503A Bulks List; it recommended the other six peptides it reviewed. Committee votes are advisory. See the regulatory position.
Screening comes first. Sleep-disordered breathing is common, frequently missed and treatable, so your clinician checks for it before anything else.
No. DSIP is not FDA-approved for any use. It is prepared by a licensed compounding pharmacy under an individual prescription.
An approved sleep medication has been reviewed by the FDA for safety and effectiveness. DSIP has not, and a compounded preparation is never equivalent to or interchangeable with an approved product. Your clinician can talk you through which options suit you.
Because sleep problems rarely have a single cause. The assessment finds what is driving yours, and DSIP is one option your clinician can include where it fits.
There is no meaningful long-term human safety data, which is different from knowing it is harmful and different from knowing it is safe. Your history and medications are reviewed before it is prescribed, and you are followed up while you are on it.
Sleep-disordered breathing first, because it is common, frequently missed and treatable. Then thyroid function, iron status, hormonal change, medications, alcohol and caffeine timing, mood and schedule. See sleep that does not restore you.
See if DSIP fits your plan
The right plan begins with knowing where you are. Start with a short eligibility check and a baseline — and we'll tell you, honestly, what fits.
We measure first. Then we act.
ACT 2 Health provides clinician-led care. Treatments described are available only to eligible patients following clinical evaluation and within applicable regulations. This page is educational and is not medical advice. Individual results vary.